Picks for week 16. Only Chicago @ Georgia is not a unanimous pick.
None of these pick methods take into account whether or not teams have anything to play for in the postseason, so take things with an extra-large grain of salt as the postseason starts to firm up.
| Game | APR | SRS | ITP |
| New Orleans VooDoo @ Orlando Predators | VooDoo ρ=1.0716 | VooDoo δ= 5.0 | VooDoo |
| Grand Rapids Rampage @ Columbus Destroyers | Rampage ρ=1.0319 | Rampage δ= 3.8 | Rampage |
| Chicago Rush @ Georgia Force | Force ρ=1.1066 | Rush δ= 2.1 | Rush |
| Cleveland Gladiators @ Philadelphia Soul | Soul ρ=1.1171 | Soul δ=10.5 | Soul |
| New York Dragons @ Dallas Desperados | Desperados ρ=1.0513 | Desperados δ= 4.8 | Desperados |
| Tampa Bay Storm @ San Jose SaberCats | SaberCats ρ=1.0466 | SaberCats δ= 1.9 | SaberCats |
| Kansas City Brigade @ Los Angeles Avengers | Avengers ρ=1.0017 | Avengers δ= 1.7 | Avengers |
| Colorado Crush @ Arizona Rattlers | Rattlers ρ=1.2154 | Rattlers δ= 4.8 | Rattlers |
